Vaccaro, Alexander R. MD, PhD; Lawrence, James P. MD, MBA; Patel, Tushar MD; Katz, Lee D. MD; Anderson, D Greg MD; Fischgrund, Jeffrey S. MD; Krop, Julie MD; Fehlings, Michael G. MD; Wong, David MD
Spine. 33(26):2850-2862, December 15, 2008.
doi: 10.1097/BRS.0b013e31818a314d
In this randomized controlled trial comparing bone graft alternatives in uninstrumented posterolateral spinal arthrodesis performed for patients with degenerative spondylolisthesis and spinal stenosis, OP-1 Putty demonstrated statistical equivalency to autograft with respect to the composite primary endpoint, relevant clinical and radiographic end points. The OP-1 Putty group also experienced statistically lower operative blood loss and shorter operative times.